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pentobarbital will reduce the level or impact of ambrisentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.pentobarbital will lower the extent or effect of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Reduced AUC of tramadol plus the Energetic metabolite (O-desmethylt